PDF Hydroquinone This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. 388, 7381 (2010), H. Li, G. Hu, F. Guo, L. Zhao, J. Zhu, Y. Zhang, Can. Boucif Belhachemi. 77, No. This is seen at about a pH of 3.50 with at least about 2.0% magnesium ascorbyl phosphate, and again at a pH of about 6.5 to about 7.0 with at least about 2.0% magnesium ascorbyl phosphate. Most preferably, when both a water-soluble antioxidant, preferably sulfite, including but not limited to sulfites, bisulfites, metabisulfites, their salts and their derivatives, most preferably sodium metabisulfite, and a cationic salt of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, are present, the color of the hydroquinone composition is stabilized in the neutral pH range, preferably for greater than about six months, more preferably for greater than about twelve months and most preferably for greater than about eighteen months. Methylaminophenol, used in photography, is produced in this way:[8]. Heat Mass Transf. An acceptable carrier also possesses suitable aesthetic and cosmetic qualities and may include emollients, conditioners and the like. 2005 Wiley-VCH, Weinheim. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. volume42, Articlenumber:1 (2021) Other antioxidants, for example cationic salts of acidic ascorbyl esters, most preferably magnesium ascorbyl phosphate, aminopropyl ascorbyl phosphate, and sodium ascorbyl phosphate, have not been utilized in combination with hydroquinone in view of the acidic pH, generally from about 3.4 to about 3.5, and the recommended pH range for magnesium ascorbyl phosphate is about 7.0 to 8.5. %PDF-1.4 % Then take the water and put the measurement into the microwave until boiled. The 10 Best Hydroquinone Creams to Buy in 2023 - Beauty Mag Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. Table II shows that at 5C, 4% hydroquinone compositions maintain their white or light straw color with the addition of at least about 0.5% magnesium ascorbyl phosphate at the low pH ranges (from about 3.50 to about 5.50) and when about 1.0 to about 2.0% magnesium ascorbyl phosphate is used in the pH range of about 7.0. Hydroquinone can be made through several routes. HMkA+"c>jZ^ho=81NW;]Ib;+i#iFArHpz). `9F6~qg3]0,#!V9Q> p=|h| Although about 0.01% sodium metabisulfite without magnesium ascorbyl phosphate may not color stabilize an about 4% hydroquinone composition, and about 0.5% magnesium ascorbyl phosphate without sodium metabisulfite may not either, the combination of sodium metabisulfite and magnesium ascorbyl phosphate in these percentages is effective to stabilize the color of the about 1% to about 12%, about 2% to about 10%, preferably about 2% to about 8% and more preferably about 3% to about 4% and most preferably 4% hydroquinone composition. As utilized herein, the inhibition of the retinoid oxidation should be sufficient to prohibit browning of the composition for its shelf life, preferably greater than about six months, more preferably greater than about twelve months, and most preferably greater than about eighteen months. Some hydroquinone compositions include antioxidants, such as ascorbyl palmitate. This is a prescription-only ingredient in some countries, including the member states of the European Union under Directives 76/768/EEC:1976. SAS Anti-ox booster 1% 0.3g. The Molecular Weight is 110.11 g/mol. 0000053439 00000 n ADS What is Hydroquinone: Properties, Uses and Applications, Examples For more information, please see our This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Thanks to the added vitamin E, it leaves your skin feeling smooth and soft, too. At 40C, 4% hydroquinone compositions have the same color stability with slightly more sodium metabisulfite, at least about 0.01% at about 3.5 to about 4.0 pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at pH; at least about 0.05% sodium metabisulfite at about 4.5 to about 6.0 pH; and at least about 0.10% sodium metabisulfite at about 6.5 to about 7.0 pH. I'd like the consistency to be thin like a gel so that it absorbs quicker. [19][20], In 2006, the United States Food and Drug Administration revoked its previous approval of hydroquinone and proposed a ban on all over-the-counter preparations. [24], Numerous studies have revealed that hydroquinone, if taken orally, can cause exogenous ochronosis, a disfiguring disease in which blue-black pigments are deposited onto the skin; however, skin preparations containing the ingredient are administered topically. Hydrquinone Cas N: 123-31-9 - Oecd n3kGz=[==B0FX'+tG,}/Hh8mW2p[AiAN#8$X?AKHI{!7. Such carriers are widely known in the art and deliver the composition's ingredients to the skin without excessive degradation, inactivation or other unwanted interaction. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), are beneficial for improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. Protected retinoid, with its skin benefit capabilities, may also be included with the hydroquinone composition. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), which are protected have been shown to also be color stable in hydroquinone, magnesium ascorbyl phosphate and sodium metabisulfite composition at about a neutral pH, preferably from about 5.5 to about 8.0, more preferably from about 5.5 to about 7.5, and most preferably from about 6.0 to about 7.5. Solubility: Moderately soluble in water, glycerin, propylene glycol, and highly soluble in ethanol Features & Benefits Can work in conjunction with glycolic acid to help reduce pigment in melasma Non-GMO Extremely low vapor pressure USP Grade European Pharma Grade Drug master file available upon request Applications This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. Without being limited to the mechanism of this discoloration, it is believed that the discoloration may be caused at least in part by oxidation of the hydroquinone. Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. They may also include ingredients with other therapeutic actions, such as anti-inflammatories, antibiotics, exfoliants and peels. It is a reducmg agent that is reversibly oxidized to semiquinone and quinone. [23] This conclusion was reached based on the extent of absorption in humans and the incidence of neoplasms in rats in several studies where adult rats were found to have increased rates of tumours, including thyroid follicular cell hyperplasias, anisokaryosis (variation in nuclei sizes), mononuclear cell leukemia, hepatocellular adenomas and renal tubule cell adenomas. 12.4. 338, 217223 (2013), S. H. Ali, F. S. Al-Mutairi, M. A. Fahim, Fluid Phase Equilib. Classical photo shops also sell hydroquinone. According to the polar paradox theory, this should lead to a dissolution of . sulfur acids, imidic, hydrazonic, hydroximic acids, Carboxylic acids, e.g. Thermodyn. An improvement in the color stability of the 4% hydroquinone compositions is seen at and above 2.0% magnesium ascorbyl phosphate in the 6-7 pH range. Cookie Notice Hydroquinone | C6H4(OH)2 - PubChem EP, Kind code of ref document: You can expect to hear from a technical specialist within 1 business hour. Obagi Nu-Derm Clear (Hydroquinone USP, 4%) Skin Bleaching Cream Obagi Hydroquinone, 99.5%, Thermo Scientific Chemicals 5g, Glass Bottle Quantity: 5g 50g 250g 1kg 5kg Packaging: Glass Bottle Plastic Drum Plastic bottle Description This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. [31], Hydroquinones are one of the two primary reagents in the defensive glands of bombardier beetles, along with hydrogen peroxide (and perhaps other compounds, depending on the species), which collect in a reservoir. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. This saturated dicarboxylic acid exists as a white powder. Natural antioxidants could replace hydroquinone derivatives used in industry. Mobility in soil No additional information available 12.5. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent. In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. Int J Thermophys 42, 1 (2021). InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H, Except where otherwise noted, data are given for materials in their. Conversion factors (at 25 oc and normal atmospheric pressure) 1 ppm = 4.5 mg!m 3 GHS P Statement: Wear protective gloves/protective clothing/eye protection/face protection.Call a POISON CENTER or doctor/physician if you feel unwell.IF ON SKIN: Gently wash with plenty of soap and water.IF IN EYES: Rinse cautiously with water for several minutes. and our Hydroquinone (C 6 H 4 (OH) 2), also known as benzene-1,4-diol or quinol, is an aromatic organic compound, with a variety of uses in chemistry. Retinoids are included from about 0.01% to about 5%, preferably from about 0.025% to about 2%, more preferably 0.05% to about 1.0%, and most preferably from about 0.025% to about 0.5%. . Thermodyn. Gravimetric method is used to measured hydroquinone solubility in water, ethanol and in water+ethanol binary mixtures at temperatures (293.15, 295.15, 298.15, 300.15, 303.15, 305.15, 308.15, 310.15 and 313.15)K. Mole fractions solubility of hydroquinone are correlated with temperature by using the Apelblat equation. Hydroquinone USP, Eastman - ChemPoint J. [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. Hydroquinone is combustible when preheated. Crit. GHS H Statement: Causes serious eye damage.Suspected of causing genetic defects.May cause an allergic skin reaction.Suspected of causing cancer.Harmful if swallowed.Very toxic to aquatic life. 0.5% magnesium ascorbyl phosphate protected at pH 6.0-7.0, 1.0-1.5% at pH 5.5-7.0, and 2.0-3.0% at pH 3.5-7.0. Then add it to the ingredients. The most preferred example of such an antioxidant is sodium metabisulfite. RJPT - Hydroquinone Solubility in Pure and Binary Solvent Mixture at The document was not able to download due to an unknown error. HYPERPIGMENTARY STAIN ELIMINATING CREAM FOR FACE SKIN AND ITS USE. Toxicol. Best Budget Hydroquinone Cream Ambi Skincare Fade Cream (56g/2oz) View on Amazon. Continue rinsing.IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.Avoid release to the environment.WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. I understand the concentrations are high but I have used them before, its just too expensive to keep buying from a compounding pharmacy. The Campaign for Safe Cosmetics has also highlighted concerns. 15, 188196 (1996), U. Domaska, Fluid Phase Equilib. The reservoir opens through a muscle-controlled valve onto a thick-walled reaction chamber. nQt}MA0alSx k&^>0|>_',G! 65, 5786 (1998), Y.-H. Zhang, Trends Analyt. Except where otherwise noted, data are given for materials in their, Hydroquinone oxidation with V2O5/NaClO3/H2SO4, http://www.sciencemadness.org/smwiki/index.php?title=Hydroquinone&oldid=11523, Articles containing unverified chemical infoboxes, GNU Free Documentation License 1.3 or later. Other aspects, advantages, and modifications are evident from a review of the following claims. Johnson & Johnson Consumer Products, Inc. Johnson & Johnson Consumer Companies, Inc. AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR, STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN, Color Stability of 4% HQ Compositions with varying pH and % Sodium Metabisulfite at 5C and 40C, Color Stability of 4% HQ Compositions with varying pH and % Magnesium Ascorbyl Phosphate at 5C and 40C, Polyacrylamide (and) C 13-14 isoparaffin (and) laureth-7, Water, Soybean (Glycine Soja) Oil, Carnauba (Copemicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Water, Soybean (Glycine Soja) Oil, Carnauba (Copernicia Cerifera), wax, tocopherol, retinol, Ceteareth-20, Compositions for the treatment of pigmentation disorders and methods for their manufacture, Stabilization composition including hydroquinone or derivative thereof, Stabilized retinol for cosmetic dermatological, and pharmaceutical compositions, and use thereof, Depigmenting composition for the skin comprising adapalene and at least one depigmenting agent, Depigmenting composition for the skin, use of a depigmenting composition for the skin, cosmetic use of the same and method for non-therapeutic cosmetic treatment, Cosmetic designs and products using intronic RNA, Holistic composition and method for reducing skin pigmentation, Topical compositions and methods of manufacturing them in specifically treated steel vessels, System for improved percutaneous absorption of skin benefiting agents, Discontinuous surface coating for particles, Method of treating skin requiring chemical peel procedure, Method of treating skin needing hyaluronic acid treatment, Method of treating skin having incision from surgical procedures, Method of treating skin requiring hair removal procedure, Method of treating skin requiring Intense Pulse Light (IPL) procedure, Method of treating skin subject to or affected by aesthetic surgical procedures, Method of treating skin needing ablative treatment, Method of treating skin requiring radiofrequency procedure, Method of treating skin requiring non-ablative procedure, Method of treating skin requiring fractional resurfacing treatment, Method of treating skin needing botulinum toxin type a treatment, Method of treating skin requiring microdermabrasion, Method of treating skin needing collagen treatment, Method of treating skin requiring skin cancer treatment, Methods of treating skin to enhance therapeutic treatment thereof, Ras mutation and compositions and methods related thereto, Compositions, kits and regimens for the treatment of skin, especially dcolletage, Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions. It is highly soluble in water (70 g/litre at 25 C) and the log n-octanol/water partition coefficient is 0.59. Solubility of phenytoin in aqueous mixtures of ethanol and sodium PDF Solubilityof Eastman hydroquinone andderivatives Get medical attention. https://doi.org/10.1007/s10765-020-02750-4, DOI: https://doi.org/10.1007/s10765-020-02750-4. Hydroquinone: Environmental Pollution, Toxicity, and Microbial Answers 0000002379 00000 n 0000000807 00000 n HVoLg~Z+ 43, 13111316 (2007), J. Qing-Zhu, M. Pei-Sheng, Z. Huan, X. Shu-Qian, W. Qiang, Q. Yan, Fluid Phase Equilib. Re: How to dissolve Hydroquinone to make 4 oz. The preferred protected retinoid is in the form of small beads or vesicles which are of a form that can be adjusted to be incorporated into varied topical compositions. The obtained results show that the solubility of benzoic acid in water is greater than that of salicylic acid, but in the case of the two isomers of dihydroxybenzene, the solubility of resorcinol is approximately 100 times that of hydroquinone. A method of stabilizing a hydroquinone composition, comprising hydroquinone and one or more protected retinoids, comprising: maintaining pH of the composition at about 5.5 to about 8.0. Consistent with a condensation reaction, water was determined to be the primary byproduct. Monobenzone: Uses, Interactions, Mechanism of Action - DrugBank Inhalation Remove to fresh air. 132, 165172 (2018), X. Li, Q. Yin, W. Chen, J. Wang, J. Chem. Hydroquinone Revision Date 24-Dec-2021 General Advice If symptoms persist, call a physician. Google Scholar, W. J. Weber Jr, Y.-P. Chin, C. P. Rice, Water Res. Color stability improvement is evident at all levels. This page was last modified on 19 June 2019, at 20:05. Approved only for prescription use in the U.S. market.Ideal for creams, lotions, and gels for personal care ingredients, pharmaceutical chemical, pharmaceutical excipients, and skin care ingredients. 2017-02-16T10:10:56+01:00 Chem. PubMedGoogle Scholar. Hydroquinone occurs as fine, white needles. A preferred embodiment utilizes encapsulation. HyTSwoc [5laQIBHADED2mtFOE.c}088GNg9w '0 Jb Hydroquinone is a major benzene metabolite, which is a well-known haematotoxic and carcinogenic agent associated with malignancy in occupational environments. EP2047846A2 - Process for stabilizing hydroquinone - Google M1 and M2 microemulsions contain ethanol as co-surfactant. Availability. 0000002221 00000 n Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. Hope it helps 6 yrs later. endstream endobj 276 0 obj <>stream 0.6. glycerin, 2.5. 230, 176183 (2005), A. Apelblat, E. Manzurola, N. A. Balal, J. Chem. The solubilities of benzoic acid, salicylic acid, resorcinol and hydroquinone in water and in 1-octanol were measured by the dynamic method which is also called the synthetic method from 297.25 K to 334.45 K. Using differential scanning calorimetry (DSC Q2000 and SDT Q600), the melting temperature and the enthalpy of fusion of these solutes were determined. Table I shows that at 5C, 4% hydroquinone compositions maintain their white color with the addition of at least about 0.01% sodium metabisulfite at the low pH ranges (from about 3.50 to about 5.50) and at least 0.05% sodium metabisulfite for pH about 6.0 to about 7.0. The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. It is also used to prepare 2% bleaching creams and certain intermediates for the synthesis of dyes, and it has some activity as an antitumoragent.